Brian Eastick has included Wilfred Zaha in his squad to face Belgium next Wednesday at the Riverside.
The Crystal Palace midfielder has earned his first call up thanks to a series of impressive performances for the Eagles this season.
Zaha has previously featured for the Young Lions at Under 19 level and has already racked up 81 appearances for his club.
Cameron Stewart is also expected to debutize as the Hull City midfielder makes the step up from the Under 20 side.
Jason Steele and Joe Bennett will play in front of a home crowd at the Riverside, both playing for the northern club Middlesbrough.
Eastick expects continuity to remain throughout the squad despite the absence of Stuart Pearce as he takes charge of the seniors.
The clash against Belgium is a top of the table fight in European Championships Qualifying Group 8.
Eastick told thefa.com “Due to the environment that Stuart has developed within the Under-21s set-up, it will hopefully be a seamless transition for this game with continuity being maintained with regards to our principles of play.”
He continued: “Stuart and I have had a good professional relationship having worked together closely during his five years at The FA. Last week I sat down with him to discuss the overall plans for this get-together and careful consideration has been given to the make-up of both the Senior and Under-21s squads.”
“There are a couple of new faces in the group, with Crystal Palace’s Wilfried Zaha and Hull City’s Cameron Stewart coming in for the first time. They both deserve their opportunities after some impressive performances at club level.”
You can catch a match report of England’s visit to the Riverside on The Youth Radar on Thursday.
Full Squad to face Belgium
Ben Amos (Manchester United), Jack Butland (Cheltenham Town – loan from Birmingham City), Jason Steele (Middlesbrough)
Joe Bennett (Middlesbrough), Ryan Bennett (Peterborough United – loan from Norwich City), Steven Caulker (Swansea City – loan from Tottenham), Craig Dawson (West Bromwich Albion), Martin Kelly (Liverpool), Danny Rose (Tottenham Hotspur), Adam Smith (Leeds United – loan from Tottenham Hotspur)
Gary Gardner (Aston Villa), Jordan Henderson (Liverpool), Henri Lansbury (West Ham United – loan from Arsenal), Jason Lowe (Blackburn Rovers), Josh McEachran (Swansea City – loan from Chelsea), Alex Oxlade-Chamberlain (Arsenal), Jonjo Shelvey (Liverpool), Cameron Stewart (Hull City), Wilfried Zaha (Crystal Palace)
Nathan Delfouneso (Leicester City – loan from Aston Villa), Will Keane (Manchester United), Marvin Sordell (Bolton Wanderers), Connor Wickham (Sunderland)