After Caen took a three-goal lead, Lille hit back to make sure they remained one of only two unbeaten teams in Group A after three matches.
They hit back in emphatic fashion as a Victor Thélot hat-trick as well as goals from Gauthier Varez (penalty) and Salah Bennan ensured they notched up five goals to remain top of the table.
PSG are the other unbeaten side and continued their run with an away win against Drancy.
17-year-old Romil Devon added to a Kevin Farade hat-trick to ensure all three points were taken from the Maurice Bacquet Stage in Drancy.
Lens 3-1 Amiens SC, Amiens AC 3-0 Racing Club, Le Havre 4-0 Quevilly, Drancy 1-4 Paris SG, Caen 3-5 Lille.
In Group B Evian remain top of the table, still without even conceding a goal as they beat Nancy 4-0 at the weekend.
Mohamed Chaibi netted a brace and goals from Corentin Tirard and Kevin Marchal saw them win on Saturday afternoon, bringing their record so far to three played, three wins, twelve scored and zero conceded.
Elsewhere Auxerre celebrated victory over Mulhouse and Sochaux remain the other team with a perfect record after beating bottom-of-the-table La Chapelle away from home.
La Chapelle 2-5 Sochaux, Epinal 1-0 Strasbourg, Metz 0-1 Dijon, Sedan 0-1 Troyes, Mulhouse 1-3 Auxerre, Reims 3-0 Pontarlier, Evian 4-0 Nancy.
A shock result saw Chateauroux defeat last season’s division winners and eventual competition finalists Nantes.
The result sees Chateauroux equal on points with the defending runners-up as they both sit on six points in the table.
Tours and Stade Laval are leading the way on seven points each with draws against Bordeaux and Le Mans respectively this weekend.
Colomiers sit bottom as the only side not to pick up a point in the league yet after they went down 3-0 against Angers this weekend.
Bayonne 1-1 Lorient, Bordeaux 2-2 Tours, Guingamp 4-1 Stade Brest, Nantes 0-2 Chateauroux, Rennes 1-1 Niort, Stade Laval 1-1 Le Mans, Angers 3-0 Colomiers.
After winning the competition last season, this term hasn’t started well for Monaco who lost their second game of the season.
Their loss at the weekend against Saint Etienne sees the former lead the table after three games.
Raphael Diarra scored Monaco’s single goal but Eliot Gattier netted an 85th minute winner for Etienne to give them all three points.
Watch video highlights of the game below.
Monaco 1-2 Saint Etienne, Cannes 1-2 Ajaccio, Le Puy 2-0 Gallia Lucciana, Lyon 6-0 Nimes, Toulouse 1-1 Montpellier